The Brain Institute draws together researchers from throughout the University, including the School of Medicine, the Dietrich School of Arts and Sciences, the Swanson School of Engineering, the Graduate School of Public Health, the School of Health and Rehabilitation Sciences, and the School of Pharmacy. A short list of Centers and programs in the Brain Institute includes the Center for the Neural Basis of Cognition, Center for Neuroscience at the University of PittsburghAlzheimer's Disease Research Center, Pittsburgh Institute for Neurodegenerative Disease, Translational Neuroscience Program, UPMC Sports Medicine Concussion Program, Aging Institute, Pittsburgh Center for Pain Research, Learning Research and Development Center, UPMC Eye Center, Louis J. Fox Center for Vision Restoration and the University of Pittsburgh Drug Discovery Institute.

The Brain Institute is organized to be inclusive and multi-disciplinary. As a consequence, the Brain Institute has the potential to develop affiliations with Pitt neuroscientists who may not be represented on this more extensive list of departments, centers and institutes. An exchange of letters with the Scientific Director of the Brain Institute constitutes the basis for forming an affiliation. A goal of the Institute is to provide a service to the entire Pitt neuroscience community.