2021 Research

Here is a sample of Pitt research published in 2021 in journals with impact factors of 5 or higher. Click on the journal title to read a specific PubMed citation. 

Transl Psychiatry. 2021 May 1
Imaging beta-amyloid (Aβ) burden in the brains of middle-aged individuals with alcohol-use disorders: a [ 11 C]PIB PET study
Margaret R Flanigan #, Sarah K Royse #, David P Cenkner, Katelyn M Kozinski, Clara J Stoughton, Michael L Himes, Davneet S Minhas, Brian Lopresti, Meryl A Butters, Rajesh Narendran 

Neurobiol Dis. 2021 Apr 30
Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia
Takeaki Miyamae, Takanori Hashimoto, Monica Abraham, Rika Kawabata, Sho Koshikizawa, Yufan Bian, Yosuke Nishihata, Mitsuru Kikuchi, G Bard Ermentrout, David A Lewis, Guillermo Gonzalez-Burgos 

Schizophr Bull. 2021 Apr 30
Peripubertal mGluR2/3 Agonist Treatment Prevents Hippocampal Dysfunction and Dopamine System Hyperactivity in Adulthood in MAM Model of Schizophrenia
Susan F Sonnenschein, Anthony A Grace 

J Cereb Blood Flow Metab. 2021 Apr 28
Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway
Ping Sun, Feifei Ma, Yang Xu, Chao Zhou, R Anne Stetler, Ke-Jie Yin 

Aging Cell. 2021 Apr 28
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration
Silas A Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H Bhatte, Victoria C Childers, Sophie A Rubin, Briana R De Miranda, Emma I O'Leary, Elizabeth G Neureiter, Keri J Fogle, Michael J Palladino, Ryan W Logan, Jill R Glausier, Kenneth N Fish, David A Lewis, J Timothy Greenamyre, Brian D McCabe, Claire E J Cheetham, Thomas S Hnasko, Zachary Freyberg 

Proc Natl Acad Sci U S A. 2021 Apr 27;
Temporally and spatially partitioned neuropeptide release from individual clock neurons
Markus K Klose, Marcel P Bruchez, David L Deitcher, Edwin S Levitan 

J Neurosci. 2021 Apr 23
VGLUT2 is a determinant of dopamine neuron resilience in a rotenone model of dopamine neurodegeneration
Silas A Buck, Briana R De Miranda, Ryan W Logan, Kenneth N Fish, J Timothy Greenamyre, Zachary Freyberg 

Cereb Cortex. 2021 Apr 19
Decoding of Attentional State Using High-Frequency Local Field Potential Is As Accurate As Using Spikes
Surya S Prakash, Aritra Das, Sidrat Tasawoor Kanth, J Patrick Mayo, Supratim Ray 

J Nucl Med. 2021 Apr 16
Direct comparison of the tau PET tracers [ 18 F]flortaucipir and [ 18 F]MK-6240 in human subjects
Alexandra Gogola, Davneet Singh Minhas, Victor L Villemagne, Ann D Cohen, James M Mountz, Tharick Ali Pascoal, Charles M Laymon, N Scott Mason, Milos D Ikonomovic, Chester A Mathis, Beth E Snitz, Oscar L Lopez, William E Klunk, Brian J Lopresti 

Annu Rev Neurosci. 2021 Apr 16.
The Cortical Motor Areas and the Emergence of Motor Skills: A Neuroanatomical Perspective
Peter L Strick, Richard P Dum, Jean-Alban Rathelot 

Neurotherapeutics. 2021 Apr 15
Ethical Considerations in Communicating Alzheimer's Disease Neuroimaging Biomarker Test Results to Symptomatic Individuals
Daniel A Wilkenfeld, Staci L Orbell, Jennifer H Lingler 

Cereb Cortex. 2021 Apr 12
The Brain Circuits and Dynamics of Curiosity-Driven Behavior in Naturally Curious Marmosets
Xiaoguang Tian, Afonso C Silva, Cirong Liu

Mol Psychiatry. 2021 Apr 9.
Astrocytes in cocaine addiction and beyond
Junshi Wang, Leanne M Holt, Hugh H Huang, Susan R Sesack, Eric J Nestler, Yan Dong 

Elife. 2021 Apr 6
Excitation of medium spiny neurons by 'inhibitory' ultrapotent chemogenetics via shifts in chloride reversal potential
Stephanie C Gantz, Maria M Ortiz, Andrew J Belilos, Khaled Moussawi 

Mov Disord. 2021 Apr 5
Lateralized Effect of Thalamic Deep Brain Stimulation Location on Verbal Abstraction
Dengyu Wang, Ahmed Jorge, Witold J Lipski, Ian H Kratter, Luke C Henry, R Mark Richardson 

J Cereb Blood Flow Metab. 2021 Apr 4
Three-dimensional remodeling of functional cerebrovascular architecture and gliovascular unit in leptin receptor-deficient mice
Yaan Liu, Di Chen, Amanda Smith, Qing Ye, Yanqin Gao, Wenting Zhang 

Nat Neurosci. 2021 Mar 29.
Learning is shaped by abrupt changes in neural engagement
Jay A Hennig, Emily R Oby, Matthew D Golub, Lindsay A Bahureksa, Patrick T Sadtler, Kristin M Quick, Stephen I Ryu, Elizabeth C Tyler-Kabara, Aaron P Batista #, Steven M Chase #, Byron M Yu #

Neuropsychopharmacology. 2021 Mar 29.
Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders
Jay C Fournier #, Michele Bertocci # ,Cecile D Ladouceur, Lisa Bonar, Kelly Monk, Halimah Abdul-Waalee, Amelia Versace, João Paulo Lima Santos, Satish Iyengar, Boris Birmaher, Mary L Phillips

J Neurosci. 2021 Mar 24
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus
Shawn F Sorrells, Mercedes F Paredes, Zhuangzhi Zhang, Gugene Kang, Oier Pastor-Alonso, Sean Biagiotti, Chloe E Page, Kadellyn Sandoval, Anthony Knox, Andrew Connolly, Eric J Huang, Jose Manuel Garcia-Verdugo, Michael C Oldham, Zhengang Yang, Arturo Alvarez-Buylla 

Psychol Med. 2021 March
Experimentally imposed circadian misalignment alters the neural response to monetary rewards and response inhibition in healthy adolescents
Brant P Hasler, Adriane M Soehner, Meredith L Wallace, Ryan W Logan, Wambui Ngari, Erika E Forbes, Daniel J Buysse, Duncan B Clark 

Cell. 2021 Mar 18
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Shiqun Zhang, Tara N Edwards, Virendra K Chaudhri, Jianing Wu, Jonathan A Cohen, Toshiro Hirai, Natalie Rittenhouse, Elizabeth G Schmitz, Paul Yifan Zhou, Benjamin D McNeil, Yi Yang, Richard Koerber, Tina L Sumpter, Amanda C Poholek, Brian M Davis, Kathryn M Albers, Harinder Singh, Daniel H Kaplan 

Am J Psychiatry. 2021 Mar 17
Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study
Rebecca B Price, Claire M Gillan. Colleen Hanlon, Fabio Ferrarelli, Tae Kim, Helmet T Karim, Marlee Renard, Rachel Kaskie, Michelle Degutis, Anna Wears, Emelina P Vienneau, Angel V Peterchev,, Vanessa Brown, Greg J Siegle, Meredith L Wallace, Susanne E Ahmari 

Am J Psychiatry. 2021 Mar 17
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps
Fabio Ferrarelli

J Neurosci. 2021 Mar 16
Mechanism of pacemaker activity in zebrafish DC2/4 dopaminergic neurons
Vladimir A Ilin, Qing Bai, Alan M Watson, Maxim Volgushev, Edward A Burton 

Transl Psychiatry. 2021 Mar 15
Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder
Sean C Piantadosi, Lora L McClain, Lambertus Klei, Jiebiao Wang, Brittany L Chamberlain, Sara A Springer, David A Lewis, Bernie Devlin, Susanne E Ahmari 

Br J Anaesth. 2021 Mar 10
Mechanistic insights into spinal neurones involved in neuraxial opioid-induced pruritus
Eileen Nguyen, Grace Lim, Sarah E Ross

Biol Psychiatry. 2021 Mar 8
Sex Differences in Molecular Rhythms in the Human Cortex
Ryan W Logan, Xiangning Xue, Kyle D Ketchesin Gabriel Hoffman, Panos Roussos, George Tseng, Colleen A McClung, Marianne L Seney 

Nat Neurosci. 2021 Mar 8
Rare rewards amplify dopamine responses
Kathryn M Rothenhoefer, Tao Hong, Aydin Alikaya, William R Stauffer

Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Mar 5
μ-Opioid antagonist naltrexone partially abolishes the antidepressant placebo effect and reduces OFC encoding of reinforcement
Marta Peciña, Jiazhou Chen, Thandi Lyew, Jordan F Karp, Alexandre Y Dombrovski

Am J Psychiatry. 2021 Mar 3
Examining and Modulating Neural Circuits in Psychiatric Disorders With Transcranial Magnetic Stimulation and Electroencephalography: Present Practices and Future Developments
Fabio Ferrarelli, Mary L Phillips 

Prog Neurobiol. 2021 Mar 2
Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence
Ashley C Parr, Finnegan Calabro, Bart Larsen, Brenden Tervo-Clemmens, Samuel Elliot, Will Foran, Valur Olafsson, Beatriz Luna 

Biol Psychiatry. 2021 Feb 19
Altered Parvalbumin Basket Cell Terminals in the Cortical Visuospatial Working Memory Network in Schizophrenia
Kenneth N Fish, Brad R Rocco, Adam M DeDionisio, Samuel J Dienel, Robert A Sweet, David A Lewis 

Neuroimage. 2021 Feb 17
The longitudinal stability of fMRI activation during reward processing in adolescents and young adults
David A A Baranger, Morgan Lindenmuth, Melissa Nance, Amanda E Guyer, Kate Keenan, Alison E Hipwell, Daniel S Shaw, Erika E Forbes 

Transl Psychiatry. 2021 Feb 16
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W Logan, Claes B Wollheim, Massimo Trucco, Vijay K Yechoor,  David R Sibley, Rita Bottino, Zachary Freyberg 

Acta Neuropathol. 2021 Feb 14.
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology
Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow

J Neurosci. 2021 Feb 10;
Outer hair cell glutamate signaling through type II spiral ganglion afferents activates neurons in the cochlear nucleus in response to non-damaging sounds
Catherine J C Weisz, Sean-Paul G Williams, Chad S Eckard, Christopher B Divito, David W Ferreira, Kristen N Fantetti, Shenin A Dettwyler, Hou-Ming Cai, Maria E Rubio, Karl Kandler, Rebecca P Seal 

Sci Transl Med. 2021 Feb 3
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition
Eileen Nguyen, Grace Lim, Huiping Ding, Junichi Hachisuka, Mei-Chuan Ko, Sarah E Ross 

PLoS Pathog. 2021 Feb 3;
Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques
Joseph R Albe, Henry Ma, Theron H Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Katherine J O'Malley, Noah Salama, Aaron W Walters, Ivona Pandrea, Tobias Teichert, William B Klimstra, Douglas S Reed, Amy L Hartman 

Mol Psychiatry. 2021 Feb 1
MAP2 is differentially phosphorylated in schizophrenia, altering its function
M J Grubisha, X Sun, M L MacDonald, M Garver, Z Sun, K A Paris, D S Patel, R A DeGiosio, D A Lewis, N A Yates, C Camacho, G E Homanics, Y Ding, R A Sweet

Biol Psychiatry. 2021 Feb 1
Prepubertal Environmental Enrichment Prevents Dopamine Dysregulation and Hippocampal Hyperactivity in MAM Schizophrenia Model Rats
Xiyu Zhu, Anthony A Grace

Mol Psychiatry. 2021 Jan 25
A specific neural substrate predicting current and future impulsivity in young adults
J Scott Steele, Michele Bertocci, Kristen Eckstrand, Henry W Chase, Richelle Stiffler, Haris Aslam, Jeanette Lockovich, Genna Bebko, Mary L Phillips

Am J Psychiatry. 2021 Jan 21;
Association of Neural Reward Circuitry Function With Response to Psychotherapy in Youths With Anxiety Disorders
Stefanie L Sequeira, Jennifer S Silk, Cecile D Ladouceur, Jamie L Hanson, Neal D Ryan, Judith K Morgan, Dana L McMakin, Philip C Kendall, Ronald E Dahl, Erika E Forbes

Dev Cogn Neurosci. 2021 Jan 20;
Lower neural value signaling in the prefrontal cortex is related to childhood family income and depressive symptomatology during adolescence
Esther E Palacios-Barrios, Jamie L Hanson, Kelly R Barr, W Dustin Albert, Stuart F White, Ann T Skinner, Kenneth A Dodge, Jennifer E Lansford 

Nat Commun. 2021 Jan 19
Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cordNathan Greiner, Beatrice Barra, Giuseppe Schiavone, Henri Lorach, Nicholas James, Sara Conti, Melanie Kaeser, Florian Fallegger, Simon Borgognon, Stéphanie Lacour, Jocelyne Bloch, Grégoire Courtine, Marco Capogrosso

Radiology. 2021 Jan 19
Molecular Imaging Approaches in Dementia
Victor L Villemagne, Frederik Barkhof, Valentina Garibotto, Susan M Landau, Agneta Nordberg, Bart N M van Berckel

Neuropsychopharmacology. 2021 Jan 15.
Beta-adrenergic blockade blunts inflammatory and antiviral/antibody gene expression responses to acute psychosocial stress
Jennifer K MacCormack, Monica M Gaudier-Diaz, Emma L Armstrong-Carter, Jesusa M G Arevalo, Samantha Meltzer-Brody, Erica K Sloan, Steven W Cole, Keely A Muscatell 

Biol Psychiatry. 2021 Jan 15
Considerations When Characterizing Adolescent Neurocognitive Development
Beatriz Luna, Brenden Tervo-Clemmens, Finnegan J Calabro 

Schizophr Bull. 2021 Jan 14
Similarities in Cortical Transcriptome Alterations Between Schizophrenia and Bipolar Disorder Are Related to the Presence of Psychosis
John F Enwright, David A Lewis 

Transl Psychiatry. 2021 Jan 12;
Involvement of the nuclear factor-κB transcriptional complex in prefrontal cortex immune activation in bipolar disorder
Kaitlyn M Roman, Aaron K Jenkins, David A Lewis, David W Volk 

J Neurosci. 2021 Jan 12
AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses
Yao Q Wang, Yanhua H Huang, Saju Balakrishnan, Li-Dong Liu, Yu Tian Wang, Eric J Nestle,, Oliver M Schlüter, Yan Dong 

Proc Natl Acad Sci U S A. 2021 Jan 12
Diurnal rhythms across the human dorsal and ventral striatum
Kyle D Ketchesin, Wei Zong, Mariah A Hildebrand, Marianne L Seney, Kelly M Cahill, Madeline R Scott, Vaishnavi G Shankar, Jill R Glausier, David A Lewis, George C Tseng, Colleen A McClung

Neurobiol Dis. 2021 Jan 9
nhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice
Yaan Liu, Sicheng Li, Rongrong Wang, Hongjian Pu, Yongfang Zhao, Qing Ye, Yejie Shi 

Autophagy. 2021 Jan 6.
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes
Meysam Yazdankhah, Sayan Ghosh, Peng Shang, Nadezda Stepicheva, Stacey Hose, Haitao Liu, Xitiz Chamling, Shenghe Tian, Mara L G Sullivan, Michael Joseph Calderon, Christopher S Fitting, Joseph Weiss, Ashwath Jayagopal, James T Handa, José-Alain Sahel, J Samuel Zigler Jr Paul R Kinchington, Donald J Zack, Debasish Sinha 


Neurology. 2021 Jan 4
Cell Therapy for Chronic TBI: Interim Analysis of the Randomized Controlled STEMTRA Trial
Masahito Kawabori, Alan H Weintraub, Hideaki Imai, Laroslav Zinkevych, Peter McAllister, Gary K Steinberg, Benjamin M Frishberg, Takao Yasuhara, Jefferson W Chen, Steven C Cramer, Achal S Achrol, Neil E Schwartz, Jun Suenaga, Daniel C Lu, Ihor Semeniv, Hajime Nakamura, Douglas Kondziolka, Dai Chida, Takehiko Kaneko, Yasuaki Karasawa, Susan Paadre, Bijan Nejadnik, Damien Bates, Anthony H Stonehouse, R Mark Richardson, David O Okonkwo

Philos Trans R Soc Lond B Biol Sc. 2021 Jan 4
Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling
Mitsuhiro Fukuda, Alexander J Poplawsky, Seong-Gi Kim

Neuropsychopharmacology. 2021 January
Critical roles for developmental hormones and genetic sex in stress-induced transcriptional changes associated with depression
Marianne L Seney, Ryan W Logan

Methods Mol Biol. 2021
Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests
Chelsea A Vadnie, Lauren M DePoy, Colleen A McClung